Alexis Dziena is most famous for the brief but awesome fully nude scene she did in the Bill Murray movie Broken Flowers (2005). This scene had to be filmed at the end of the movie's production so Alexis could actually turn 18. Richard Roeper listed her performance as one of the five "Most startling nude scenes of the year" for 2005. As Bill Murray's character put it in the movie, "That was quite an outfit you weren't wearing earlier."
Dziena was born in New York City of Irish, Italian, and Polish descent. She attended Saint Ann's School alongside her Bringing Rain (2003) costar, Paz de la Huerta. She spent many of her summers growing up in the small South Jersey shore town of Sea Isle City. Also, during high school, she attended classes at the American Academy of Dramatic Arts and appeared in plays there as well. She appeared as a character called Lolita (a reference to Vladimir Nabokov's novel Lolita) in Broken Flowers, where her character surprises a character played by Bill Murray by walking into a room full frontally nude. In the ABC television series Invasion she played the sheriff's daughter Kira Underlay. She made her acting debut in TNT's Witchblade.
In addition to acting, she is a budding playwright and drummer. She dated actor Michael Pitt.